業績Publications

Ono Y, Kaku M, Thant L, Iwama H, Arai M, Mizukoshi M, Dobashi A, Kitami M, Taketo MM, Ohazama A, Saito I, Uoshima K. Wnt/β-catenin promotes cementum apposition in periodontal regeneration. J Dent Res. In Press

Kawasaki M, Kawasaki K, Sari FT, Kudo T, Nihara J, Kitamura M, Nagai T, Utama V, Ishida Y, Meguro F, Kesuma A, Fujita A, Nishimura T, Kogure Y, Maruyama S, Tanuma J, Kakihara Y, Maeda T, Ghafoor S, Khonsari RG, Corre P, Sharpe PT, Cobourne MT, Franco B, Ohazama A. Cell-cell interaction determine cell fate of mesoderm-derived cell in tongue development through Hh signaling. eLife 11:13:e85042, 2024.

Kantaputra P, Daroontum T, Kitiyamas K, Piyakhunakorn P, Kawasaki K, Sathienkijkanchai A, Wasant P, Vatanavicharn N, Yasanga T, Kaewgahya M, Tongsima S, Cox TC, Arold ST, Ohazama A, Ngamphiw C. PLEC is a novel gene for congenital insensitivity to pain. Int J Mol Sci. 8;25(12):6358, 2024.

Ruangchan C, Ngamphiw C, Krasaesin A, Intarak N, Tongsima S, Kaewgahya M, Kawasaki K, Mahawong P, Paripurana K, Sookawat B, Jatooratthawichot P, Cox TC, Ohazama A, Cairns JRK, Porntaveetus T, Kantaputra P. Genetic variants in KCTD1 are associated with isolated dental anomalies. Int J Mol Sci. 9;25(10):5179, 2024.

Ida-Yonemochi H, Otsu K, Irié T, Ohazama A, Harada H, Ohshima H. Loss of autophagy disrupts stemness of ameloblast-lineage cells in aging. J Dent Res. 103(2):156-166, 2024.

Kantaputra P, Butali A, Eliason S, Chalkley C, Nakornchai S, Bongkochwilawan C, Kawasaki K, Kumchiang A, Ngamphiw C, Tongsima S, Ketudat Cairns JR, Olsen B, Intachai W, Ohazama A, Tucker AS, Amendt BA. CACNA1S mutation-associated dental anomalies: A calcium channelopathy. Oral Dis. 30(3):1350-1359, 2024.

Kantaputra P, Leelaadisorn N, Hatsadaloi A, Quarto N, Intachai W, Tongsima S, Kawasaki K, Ohazama A, Ngamphiw C, Wiriyakijja P. A mutation in CACNA1S results in impaired calcium homeostasis and dental anomalies. Diagnostics (Basel). 13:895, 2023.

Kantaputra P, Jatooratthawichot P, Adisornkanj P, Kitsadayurach P, Kaewgahya M, Olsen B, Ohazama A, Ngamphiw C, Tongsima S, Cox TC, Cairns JRK. Rare variants in LRP4 are associated with mesiodens, root maldevelopment, and oral exostoses in humans. Biology (Basel). 12:220, 2023.

Kudo T, Kawasaki M, Kawasaki K, Meguro F, Nihara J, Honda I, Kitamura M, Fujita A, Osawa K, Ichikawa K, Nagai T, Ishida Y, Sharpe PT, Maeda T, Saito I, Ohazama A. Ift88 regulates enamel formation via involving Shh signaling. Oral Dis. 29:1622-1631, 2023. 

Yamada Y, Nihara J, Trakanant S, Kudo T, Seo K, Iida I, Izumi K, Kurose M, Shimomura Y, Terunuma M, Maeda T, Ohazama A. Perivascular Hedgehog responsive cells play a critical role in peripheral nerve regeneration via controlling angiogenesis. Neurosci Res 173:62-70, 2021.

Nihara J, Kawasaki M, Kawasaki K, Yamada A, Meguro F, Kudo T, Trakanant S, Nagai T, Fujita A, Honda I, Saito I, Maeda T, Ohazama A, Expression of R-spondins/Lgrs in development of movable craniofacial organs, Gene Expr Patterns, 41:119195, 2021.

Kantaputra　PN, Dejkhamron　P, Intachai　W, Ngamphiw　C, Ketudat Cairns　J R, Kawasaki　K, Ohazama　A, Olsen　B, Tongsima　S, Angkurawaranon　S. A novel P3H1 mutation is associated with Osteogenesis imperfecta type VIII and dental anomalies. Oral Surg Oral Med Oral Pathol Oral Radiol. 28:4564, 2021

Trakanant S, Nihara J, Nagai T, Kawasaki M, Kawasaki K, Ishida Y, Meguro F, Kudo T, Yamada A, Maeda T, Saito I, Ohazama A. MicroRNAs regulate distal region of mandibular development through Hh signaling. J Anat. 238:711-719, 2021.

Kantaputra PN, Dejkhamron P, Intachai W, Ngamphiw C, Kawasaki K, Ohazama A, Krisanaprakornkit S, Tongsima S, Ketudat Cairns JR. Juberg-Hayward syndrome is a cohesinopathy, caused by mutations in ESCO2. Eur J Orthod. 43:45-50, 2021

Yamada A, Kawasaki M, Miake Y, Yamada Y, Blackburn J, Kawasaki K, Trakanant S, Nagai T, Nihara J, Kudo T, Meguro F, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Maeda T, Takagi R, Ohazama A. Overactivation of the NF-kB pathway impairs molar enamel formation, Oral Dis. 26:1513-1522, 2020.

Kantaputra P, Pruksachatkunakorn C, Intachai W, Ohazama A, Carlson Br, Kawasaki K, Chuamanochan, M. Clouston syndrome with pili canaliculi, pili torti, overgrown hyponychium, onycholysis, taurodontism, and absence of palmoplantar keratoderma. J Dermatol. 47:e230-e232, 2020.

Yamada Y, Trakanant S, Nihara J, Kudo T, Seo K, Saeki M, Kurose M, Matsumaru D, Maeda T, Ohazama A, Gli3 is a key factor in the Schwann cells from both intact and injured peripheral nerves, Neuroscience, 432;229-239, 2020.

Yamada A, Nagai T, Kitamura A, Kawasaki M, Kawasaki K, Kodama Y, Maeda T, Ohazama A, Takagi R. Changes in signaling pathways in the palatal cleft in CL/Fr, J Oral Maxillofac Surg Med Pathol, 32;331-335, 2020

Trakanant S, Nihara J, Kawasaki M, Meguro F, Yamada A, Kawasaki K, Maeda T, Ohazama A, Molecular mechanisms in palatal rugae development, J Oral Biosci, 62; 30-35, 2020

Kitamura A, Kawasaki M, Kawasaki K, Meguro F, Yamada A, Nagai T, Kodama Y, Trakanant S, Sharpe PT, Maeda T, Takagi R, Ohazama A, Ift88 is involved in mandibular development, J Anat, 236:317-324, 2020

Kakihara Y, Kiguchi T, Ohazama A, Saeki M. R2TP/PAQosome as a promising chemotherapeutic target in cancer, Jpn Dent Sci Rev, 56:38-42, 2020

Nakaniwa M, Kawasaki M, Kawasaki K, 2, Yamada A, Meguro F, Maeda T, Ohazama A. Primary cilia in murine palatal rugae development, Gene Expr Patterns, 34: 119062, 2019

Meguro F, Porntaveetus T, Kawasaki M, Kawasaki K, Yamada A, Kakihara Y, Saeki M, Tabeta K, Kessler JA, Maeda T, Ohazama A. Bmp signaling in molar cusp formation, Gene Expr Patterns, 32: 67-71, 2019.

Kanemaru H, Yamada Y, Ohazama A, Maeda T, Seo K, Semaphorin 3A Inhibits nerve regeneration during early stage after Inferior alveolar nerve transection. Sci Rep, 12:4245, 2019.

Watanabe M, Kawasaki M, Kawasaki K, Kitamura A, Nagai T, Kodama Y, Meguro F, Yamada A, Sharpe PT, Maeda T, Takagi R, Ohazama A. Ift88 limits bone formation in maxillary process through suppressing apoptosis. Arch Oral Biol, 101:43-50, 2019

Kantaputra PN, Pruksametanan A, Phondee N, Kawasaki K, Ohazama A, Ketudat Cairns JR, ADAMTSL1 and mandibular prognathism, Clin Genet, 95:507-515, 2019

Nagai T, Trakanant S, Kawasaki M, Kawasaki K, Yamada Y, Watanabe M, Blackburn J, Otsuka-Tanaka Y, Hishinuma M, Kitatmura A, Meguro F, Yamada A, Kodama Y, Maeda T, Zhou Q, Saijo Y, Yasue A, Sharpe PT, Hindges R, Ritsuo Takagi, Ohazama A. The microRNAs control eyelid development through regulating Wnt signaling, Dev Dyn 248:201-210, 2019

Nishida Y, Yamada Y, Kanemaru H, Ohazama A, Maeda T, Seo K. Vasucularization via activation of VEGF-VEGFR signaling is essentiall for peripheral nerve regeneration. Biomed Res. Biomed Res. 39:287-294, 2018.

Kawasaki M, Kawasaki K, Meguro F, Yamada A, Ishikawa R, Porntaveetus P, Blackburn J, Otsuka-Tanaka Y, Saito N, Ota MS, Sharpe PT, Kessler JA, Herz J, Cobourne MT, Maeda T, Ohazama A. Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms, PLos ONE  20:e0204126, 2018

Ishikawa R, Kawasaki M, Kawasaki K, Yamada A, Trakanant S, Meguro F, Kitamura A, Kudo T, Maeda T, Ohazama A, Sox genes show spatio-temporal expression during murine tongue and eyelid development, Int J Dent, Oct 9:1601363, 2018<

Porntaveetus T, Abid MF, Theerapanon T, Srichomthong C, Ohazama A, Kawasaki K, Kawasaki M, Suphapeetiporn K, Sharpe PT, Shotelersuk V. Expanding the Oro-Dental and Mutational Spectra of Kabuki Syndrome and Expression of KMT2D and KDM6A in Human Tooth Germs. Int J Biol Sci, 14:381-389, 2018.

Yamada Y, Ohazama A, Maeda, Kenji Seo K. The Sonic Hedgehog Signaling Pathway Regulates Inferior Alveolar Nerve Regeneration. Neuroscience Letters, 671; 114-119, 2018

Kantaputra PN, Kapoor S, Verma P, Kaewgahya M, Kawasaki K, Ohazama A, Ketudat Cairns JR. Al-Awadi-Raas-Rothschild syndrome with dental anomalies and a novel WNT7A mutation, Eur J Med Genet, 60; 695-700, 2017

Suda D, Ohazama A, Maeda T, Kobayashi T. The effect of bone mass and architecture on mandibular condyle after mandibular distraction. Oral Surg Oral Med Oral Pathol Oral Radiol. 124; 339-347, 2017

Tanasubsinn N, Sittiwangkul R, Pongprot Y, Kawasaki K, Ohazama A, Sastraruji T, Kaewgahya M, Kantaputra PN, TFAP2B mutation and dental anomalies, J Hum Genet. 62:769-775, 2017

Porntaveetus T, Srichomthong C, Ohazama A, Suphapeetiporn K, Shotelersuk V. A novel GJA1 mutation in oculodentodigital dysplasia with extensive loss of enamel. Oral Dis, 23:795-800, 2017

Maeda T, Yamada Y, Ohazama A, Seo K. High potential for neuroplasticity in the mechanoreceptive Ruffini endings in the periodontal ligament. Proceedings of the 7th Temuuuuu Ilmiah National and 4th Joint Scietntific Meeting in Dentistry 2017 (ed. By D. Setijianto), Universitas Airlangga, Surabaya, Indonesia

Kawasaki M, Kawasaki K, Oommen S, Blackburn J, Watanabe M, Nagai T, Kitamura A, Maeda T, Liu B, Schmidt-Ullrich R, Akiyama T, Inoue J, Hammond NL, Sharpe PT, Ohazama A, Regional regulation of filiform tongue papillae development by Ikkα/Irf6 Dev Dyn, 245:937-946, 2016

Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, Nagai T, Kitatmura A, Nishikawa A, Kodama Y, Takagi R, Maeda T, Sharpe PT, Ohazama A. Spatio-temporal expression of Sox genes in murine palatogenesis, Gene Expr Patterns, 21:111-118, 2016

Navein AE, Cooke EJ, Davies JR, Smith TG, Wells LHM, Ohazama A, Jones NC, Healy C, Sharpe PT, Evans SL, Evans BAJ, Votruba M, Wells T, Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity, Hum Mol Genet, 25; 2404-2416, 2016.

Nozawa-Inoue K, Harada F, Magara J, Ohazama A, Maeda T. Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint. J Anat. 228:520-529, 2016

Kawasaki M, Kawasaki K, Blackburn J, Ohazama A: Molecular mechanisms regulating tooth number, Sasaki K, Suzuki O, Takahashi N (eds), Interface Oral Health Science 2016: Innovative Research on Biosis-Abiosis Intelligent Interface. Springer Singapore, 2016. 147-162.

Ohazama A, Sharpe PT. Development of epidermal appendages; teeth and hair. In; Epstein’s Inborn Errors of Development. The molecular basis of clinical disorders of morphogenesis. Third Edition. Erickson RP and Wynshaw-Boris A eds. Oxford University Press, Oxford, New York. 205-220. 2016

Kantaputra PN, Kaewgahya M, Hutsadaloi A, Vogel P, Kawasaki K, Ohazama A, Cairns JRK. GREMLIN 2 Mutations and Dental Anomalies J Dent Res, 94:1646-52, 2015

Kawasaki K, Kawasaki M, Watanabe M, EIdrus E, Nagai T, Oommen S, Maeda T, Hagiwara N, Que J, Sharpe PT, Ohazama A. Expression of Sox genes in tooth development. Int J Dev Biol, 59:471-478, 2015

Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterková R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez A, Sharpe PT, Ohazama A, Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium, J Dent Res 94, 121-128, 2015

Ohazama A, Sharpe PT. Craniofacial Development and Growth in Polycystic Kidney Disease, In: Polycystic Kidney Disease. Xiaogang Li (Editor), Codon Publications, Australia, 457-470, 2015

Tananuvat N, Charoenkwan P, Ohazama A, Cairns JRK, Kaewgahya M, Kantaputra PN. Root Dentin anomaly and a PLG mutation. Eur J Med Genet, 57:630-5, 2014

Khonsari RH, Dutel H, Charles C, Healy C, Ohazama A, Sharpe PT, Viriot L, Tafforeau P. Submicron Imaging of Soft-Tissues Using Low-Dose Phase-Contrast X-Ray Synchrotron Microtomography With an Iodine Contrast Agent. Anat Rec (Hoboken). 297, 1803-1807, 2014

de Sousa SF, Kawasaki M, Kawasaki K, Angelova A, Gomez RS, Gomes CC, Sharpe, PT, Ohazama A: PKA regulatory subunit expression in tooth development, Gene Expr. Patterns, 15:46-51, 2014

Kantaputra PN, Bongkochwilawan C, Kaewgahya M, Ohazama A, Kayserili H, Erdem AP, Aktoren O, Guven Y. Enamel-Renal-Gingival Syndrome, Hypodontia, and a Novel FAM20A mutation. Am J Med Genet A, 164:2124-2128, 2014

Kawasaki M, Porntaveetus T, Kawasaki K, Oommen S, Otsuka-Tanaka Y, Hishinuma M, Nomoto T, Maeda T, Takubo K, Suda T, Sharpe PT, Ohazama A. R-spondins/Lgrs expression in tooth development. Dev Dyn. 243:844-851, 2014

Khonsari RH, Friess M, Nysjö J, Odri G, Malmberg F, Nyström I, Messo E, Hirsch JM, Cabanis EA, Kunzelmann KH, Salagnac JM, Corre P, Ohazama A, Sharpe PT, Charlier P, Olszewski R. Shape and volume of craniofacial cavities in intentional skull deformations. Am J Phys Anthropol. 151:110-119, 2013

Khonsari RH, Ohazama A^*, Raouf R, Kawasaki M,  Kawasaki K, Porntaveetus T, Ghafoor S, Hammond P, Suttie M, Odri GA, Sandford RN, Wood JN, Sharpe PT.  Multiple postnatal craniofacial anomalies are characterized by conditional loss of Polycystic Kidney Disease 2 (Pkd2).  Hum Mol Genet 22: 1873-1885, 2013 * Corresponding Authors

Otsuka-Tanaka Y, Oommen S, Kawasaki M, Kawasaki K, Imam N, Jalani-Ghazani F, Hindges R, Sharpe PT, Ohazama A. Oral lining mucosa development depends on mesenchymal microRNAs. J Dent Res 92: 229-234, 2013

Khonsari RH, Olivier J, Vigneaux P, Sanchez S, Ta oreau P, Ahlberg PE, Di Rocco F, Bresch D, Corre P, Ohazama A, Sharpe PT, Calvez V. A mathematical model for mechanotransduction at the early steps of suture formation. Proc R Soc B 280: 20122670, 2013

Khonsari RH, Seppala M, Pradel A, Dutel H, Clément G, Lebedev O, Ghafoor S, Rothova M, Tucker A, Maisey JG, Fan CM, Kawasaki M, Ohazama A, Tafforeau P, Franco B, Helms J, Haycraft CJ, David A, Janvier P, Cobourne MT, Sharpe PT. The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling. BMC Biol. 11:27, 2013.

Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, Ghafoor S, Otsuka-Tanaka Y, Young NJ, Okamatsu Y, McGrath J, Koopman P, Sharpe PT, Ohazama A. Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLos ONE. 9: e43857, 2012.

Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree RB, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte BC, Hammond NL, Dixon MJ, Sharpe PT. The role of Irf6 in tooth epithelial invagination. Dev Biol. 365: 61-70, 2012.

Economou AD, Ohazama A, Porntaveetus T, Sharpe PT, Kondo S, Basson MA, Gritli-Linde A, Cobourne MT, Green JBA. Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate. Nat Genet. 44: 348-51, 2012.

Miletich I, Yua WY, Zhanga R, Yang K, Caixeta de Andrade S, Pereira SF, Ohazama A, Mock OB, Buchner G, Sealby J, Webster Z, Zhao M, Bei M, Sharpe PT. Developmental stalling and organ-autonomous regulation of morphogenesis. Proc Natl Acad Sci USA. 108: 19270-19275, 2011.

Ohazama A, Blackburn J, Porntaveetus T, Ota MS, Choi HY, Johnson EB, Myers P, Oommen S, Eto K, Kessler JA, Kondo T, Fraser, GJ, Streelman JT, Pardiñas UFJ, Tucker A, Ortiz PE, Charles C, Viriot L, Herz J, Sharpe PT. A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition. Proc Natl Acad Sci USA. 107: 92-97, 2010.

Ohazama A, Haycraft CJ, Seppala M, Blackburn J, Ghafoor S, Cobourne M, Martinelli DC, Fan CM, Peterkova R, Lesot H, Yoder BK, Sharpe P. Primary cilia regulate Shh activity in the control of molar tooth number. Development. 136: 897-903, 2009.

Ohazama A, Johnson EB, Ota MS, Choi HJ, Porntaveetus T, Oommen S, Itoh N, Eto K, Gritli-Linde A, Herz J, Sharpe PT. Lrp4 modulates extracellular integration of cell signaling pathways in development. PLos ONE. 3: e4092, 2008.

Ohazama A, Tucker AS, Sharpe PT. Organised tooth-specific cellular differentiation stimulated by BMP4. J Dent Res. 84: 603-606, 2005.

Ohazama A, Modino SAC, Miletich I, Sharpe PT. Stem cell-based tissue engineering of murine teeth. J Dent Res. 83: 518-522, 2004.

Ohazama　A, Hu　Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe. A dual role for Ikka in tooth development. Dev Cell. 6: 219-227, 2004.

Ohazama A, Courtney JM, Sharpe PT. Opg, Rank and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis J Dent Res. 83: 241-244, 2004.