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口腔バイオフィルムの制御戦略の開発 |
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Maki Sotozono, Ryouhei Takahashi, Takako Ida, Ryoko Nagata, Rui Saito, Niraya Kornsombut, Jutharat Manuschai, Shoji Takenaka, Yuichiro Noiri: Interaction between the human dental microbiome and host gingival model. Microbiota and Host 3(1):e240008, 2024 |
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Sotozono M, Kuriki N, Asahi Y, Noiri Y, Hayashi M, Motooka D, Nakamura S, Yamaguchi M, Iida T, Ebisu S: Impact of sleep on the microbiome of oral biofilms. PLoS One. 2021 Dec 9;16(12):e0259850.doi:10.1371/journal.pone.0259850. eCollection 2021. |
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Suzuki Y, Ohsumi T, Isono T, Nagata R, Hasegawa T, Takenaka S, Terao Y, Noiri Y: Effects of a sub-minimum inhibitory concentration of chlorhexidine gluconate on the development of in vitro multi-species biofilms. Biofouling, 36(2):146-158, 2020. doi:10.1080/08927014.2020.1739271. |
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Hasegawa T, Takenaka S, Ohsumi T, Ida T, Ohshima H, Terao Y, Naksagoon T, Maeda T, Noiri Y: Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin Oral Investig, 24 (2): 963-970, 2020. doi: 10.1007/s00784-019-02991-0. |
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Takenaka S, Ohsumi T, Noiri Y: Evidence-based strategy for dental biofilms: current evidence of mouthwashes on dental biofilm and gingivitis. Jpn Dent Sci Rev, 55 (1): 33-40, 2019. doi: 10.1016/j.jdsr.2018.07.001. |
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Sakaue Y, Takenaka S, Ohsumi T, Domon H, Terao Y, Noiri Y: The effect of chlorhexidine on dental calculus formation: an in vitro study. BMC Oral Health, 18 (1): 52, 2018. doi: 10.1186/s12903-018-0517-3. |
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Yoneda N, Noiri Y, Matsui S, Kuremoto K, Maezono H, Ishimoto T, Nakano T, Ebisu S Hayashi M: Development of a root canal treatment model in the rat. Sci Rep, 7 (1): 3315, 2017. doi: 10.1038/s41598 017-03628-6. |
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Wake N, Asahi Y, Noiri Y, Hayashi M, Motooka D, Nakamura S, Gotoh K, Miura J, Michi H, Iida T, Ebisu S: Temporal dynamics of bacterial microbiota in human oral cavity determined using an in situ model of dental biofilms. NPJ Biofilms Microbiomes, 2: 16018, 2016. doi: 10.1038/npjbiofilms.2016.18. |
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口腔バイオフィルム細菌と全身の健康 |
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Nagata R, Sato H, Takenaka S, Yokoyama J, Terai S, Mimuro H, Noiri Y: Analysis of Genetic Relatedness between Gastric and Oral Helicobacter pylori in Patients with Early Gastric Cancer Using Multilocus Sequence Typing. Int J Mol Sci 24(3):2211, 2023. |
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Noiri Y, Nagata R: Current status of gastric and oral infection/diseases caused by Helicobacter pylori. Oral Sci Int 1-8, 2023. |
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Takenaka S, Sotozono M, Yashiro A, Saito R, Kornsombut N, Naksagoon T, Nagata R, Ida T, Edanami N, Noiri Y: Efficacy of Combining an Extraoral High-Volume Evacuator with Preprocedural Mouth Rinsing in Reducing Aerosol Contamination Produced by Ultrasonic Scaling. Int. J. Environ. Res. Public Health 2022, 19(10), 6048; 16 May 2022. |
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Nagata R, Ohsumi T, Takenaka S, Noiri Y: Current prevalence of oral Helicobacter pylori among Japanese adults determined using a nested polymerase chain reaction assay. Pathogens 10(1): 10, 2020. |
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Sato K, Takahashi N, Kato T, Matsuda Y, Yokoji M, Yamada M, Nakajima T, Kondo N, Endo N, Yamamoto R, Noiri Y, Ohno H, Yamazaki K：Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system. Sci Rep, 31; 7 (1): 6955, 2017. doi: 10.1038/s41598-017-07196-7. |
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Kawahara T, Murakami S, Noiri Y, Ehara A, Takemura N, Furukawa S, Ebisu S: Effects of Cyclosporin-A-induced immunosuppression on periapical lesions in rats. J Dent Res 83 (9): 683-687, 2004. doi: 10.1177/154405910408300905 |
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Ohyama H, Nakasho K, Yamanegi K, Noiri Y, Kuhara A, Kato-Kogoe N, Yamada N, Hata M, Nishimura F, Ebisu S, Terada N: An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria. Jpn J Infect Dis, 62 (5): 381-383, 2009. |
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歯髄の創傷の治癒を促す新たなメカニズムの解析 |
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Takahara S, Ohkura N, Yoshiba N, Baldeon-Gutierrez R, Gomez-Kashimoto S, Edanami N, Ida T, Takenaka S, Yoshiba K, Noiri Y: Influence of Tooth Maturity on Healing Outcomes in Regenerative Endodontics. J Dent Res, 2025 (in press). |
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Rosa BG, Naoto O, Kunihiko Y, Nagako Y, Aiko T, Ryosuke T, Razi Saifullah IB, Naoki E, Shintaro T, Susan GK, Takako I, Yuichiro N: Wound-healing processes after pulpotomy in the pulp tissue of type 1 diabetes mellitus model rats. J Endod 50(2): 196-204, 2024. |
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Ohkura N, Yoshiba K, Yoshiba N, Edanami N, Ohshima H, Takenaka S, Noiri Y: SVCT-GLUT-mediated ascorbic acid transport pathway in rat dental pulp and its effects during wound healing. Sci Rep 23;12(1); 1251, 2023. |
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Ohkura N, Yoshiba K, Yoshiba N, Oda Y, Edanami N, Ohshima H, Takenaka S, Okiji T, Noiri Y: Prostaglandin E2-transporting pathway and its roles via EP2/EP4 in cultured human dental pulp. J Endod 49(4): 410-418, 2023. |
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Yoshiba N, Edanami N, Ohkura N, Maekawa T, Takahashi N, Tsuzuno T, Maeda T, Tabeta K, Izumi K, Noiri Y, Yoshiba K: Laminin Isoforms in Human Dental Pulp: Lymphatic Vessels Express Laminin-332, and Schwann Cell-Associated Laminin-211 Modulates CD163 Expression of M2-like Macrophages. ImmunoHorizons. 5(12):1008-1020, 2021. doi: 10.4049/immunohorizons.2100110. |
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Yoshiba N, Edanami N, Ohkura N, Maekawa T, Takahashi N, Tohma A Izumi K, Maeda T, Hosoya A, Nakamura H, Tabeta K, Noiri Y, Yoshiba K: M2 Phenotype Macrophages Colocalize With Schwann Cells in Human Dental Pulp. J Dent Res, 99 (3): 329-338, 2020. doi: 10.1177/0022034519894957. |
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Tohma A, Ohkura N, Yoshiba K, Takeuchi R, Yoshiba N, Edanami N, Shirakashi M, Ibn Belal RS, Ohshima H, Noiri Y: Glucose transporter 2 and 4 are involved in glucose supply during pulpal wound healing after pulpotomy with mineral trioxide aggregate in rat molars. J Endod, 46 (1): 81-88, 2020. doi: 10.1016/j.joen.2019.10.003. |
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Takeuchi R, Ohkura N, Yoshiba K, Tohma A, Yoshiba N, Edanami N, Shirakashi M, Belal RS, Ohshima H, Noiri Y: Immunohistochemistry and gene Expression of GLUT1, RUNX2 and MTOR in reparative dentinogenesis. Oral Dis, 26 (2): 341-349, 2020. doi: 10.1111/odi.13230. |
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Edanami N, Yoshiba N, Ohkura N, Takeuchi R, Tohma A, Noiri Y, Yoshiba K: Characterization of Dental Pulp Myofibroblasts in Rat Molars after Pulpotomy. J Endod, 43 (7): 1116-1121: 2017. doi: 10.1016/j.joen.2017.02.018. |
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歯髄疾患及び根尖性歯周組織疾患の実験病理学的研究 |
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Edanami N, Belal RSI, Yoshiba K, Yoshiba N, Ohkura N, Takenaka S, Noiri Y. Effect of a resin-modified calcium silicate cement on inflammatory cell infiltration and reparative dentin formation after pulpotomy in rat molars. Aust Endod J. 2021. doi: 10.1111/aej.12568. |
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Edanami N, Yoshiba K, Shirakashi M, Ibn Belal RS, Yoshiba N, Ohkura N, Tohma A, Takeuchi R, Okiji T, Noiri Y: Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars. Sci Rep 10(1): 20967, 2020. |
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Hasegawa T, Venkata Suresh V, Yahata Y, Nakano M, Suzuki S, Suzuki S, Yamada S, Kitaura H, Mizoguchi I, Noiri Y, Handa K, Saito M: Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation. Sci Rep 11(1):2613, 2021. |
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Ohkura N, Edanami N, Takeuchi R, Tohma A, Ohkura M, Yoshiba N, Yoshiba K, Ida-Yonemochi H, Ohshima H, Okiji T, Noiri Y: Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars.
Sci Rep, 31;7 (1): 6870, 2017. doi: 10.1038/s41598-017-07167-y. |
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Kuremoto K, Noiri Y, Ishimoto T, Yoneda N, Yamamoto R, Maezono H, Nakano T, Hayashi M, Ebisu S: Promotion of endodontic lesions in rats by a novel extraradicular biofilm model using obturation materials. Appl Environ microbiol, 80 (13): 3804-3810, 2014. doi: 10.1128/AEM.00421-14. |
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Ohkura N, Shigetani Y, Yoshiba N, Yoshiba K, Okiji T: Prostaglandin transporting protein-mediated prostaglandin E2 transport in lipopolysaccharide-inflamed rat dental pulp. J Endod, 40 (8): 1112-1117, 2014. doi: 10.1016/j.joen.2013.12.024. |
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歯科保存治療材料の開発に関する研究 |
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Niraya Kornsombut, Shoji Takenaka, Jutharat Manuschai, Maki Sotozono, Ryoko Nagata, Takako Ida, Risako Sato, Rui Saito, Ryouhei Takahashi, Daichi Sato, Yuichiro Noiri: Effects of Tooth Desensitizers on Streptococcus mutans Biofilm Formation Using a Modified Robbins Device Flow Cell System. International Journal of Molecular Sciences 25(19) 10703, 2024 |
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Manuschai J., Sotozono M., Takenaka S., Kornsombut N., Takahashi R., Saito R., Nagata R., Ida T., Noiri Y: In Vitro Inhibitory Effect of Silver Diamine Fluoride Combined with Potassium Iodide against Mixed-Species Biofilm Formation on Human Root Dentin Antibiotics 13(8); 743, 2024 |
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Kornsombut N, Takenaka S, Sotozono M, Nagata R, Ida T, Manuschai J, Saito R, Takahashi R, Noiri Y: Antibiofilm Properties and Demineralization Suppression in Early Enamel Lesions Using Dental Coating Materials. Antibiotics (Basel). 2024 Jan 22;13(1):106. |
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Edanami N, Belal RSI, Takenaka S, Yoshiba K, Gutierrez REB, Takahara S, Yoshiba N, Ohkura N, Noiri Y: In vivo assessment of the calcium salt-forming ability of a new calcium silicate-based intracanal medicament: Bio-C Temp. Dent J 11(4): 91, 2023. |
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Belal RSI, Edanami N, Yoshiba K, Yoshiba N, Ohkura N, Takenaka S, Noiri Y. Comparison of calcium and hydroxyl ion release ability and in vivo apatite-forming ability of three bioceramic-containing root canal sealers. Clin Oral Investig. 2022; 26: 1443-1451. |
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Edanami N, Belal RSI, Takenaka S, Yoshiba K, Yoshiba N, Ohkura N, Noiri Y. Apatite-forming ability of flowable vs. putty formulations of newly developed bioactive glass-containing endodontic cement. Appl Sci. 2021; 11: 8969. |
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Naksagoon T, Takenaka S, Nagata R, Sotozono M, Ohsumi T, Ida T, Edanami N, Maeda T, Noiri Y. A repeated state of acidification enhances the anticariogenic biofilm activity of glass ionomer cement containing fluoro-zinc-silicate fillers. Antibiotics. 2021; 10: 977. |
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Naksagoon T, Ohsumi T, Takenaka S, Nagata R, Hasegawa T, Maeda T, Noiri Y: Effect of water aging on the anti-biofilm properties of glass ionomer cement containing fluoro-zinc-silicate fillers. Biofouling 36(9):1090-1099, 2020. |
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Matsui S, Yoneda N, Maezono H, Kuremoto K, Ishimoto T, Nakano Y, Yumoto H, Ebisu S, Noiri Y, Hayashi M: Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats. PLOS ONE 15(9): e0239660, 2020.
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Yamamoto S, Han L, Noiri Y, Okiji T: Evaluation of the Ca ion release, pH and surface apatite formation of a prototype tricalcium silicate cement. Int Endod J, 50 Suppl 2: e73-e82, 2017. doi: 10.1111/iej.12737. |
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根面う蝕の新しい病因論の提唱と新規制御戦略 |
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Takenaka S, Edanami N, Komatsu Y, Nagata R, Naksagoon T, Sotozono M, Ida T, Noiri Y. Periodontal pathogens inhabit root caries lesions extending beyond the gingival margin: a next-generation sequencing analysis. Microorganisms. 2021; 9: 2349. |
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シミュレーション教育システムの開発と応用 |
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Niwano K, Okiji T, Noiri Y: Novel analysis of endodontic file manipulation using a newly developed apparatus for recording force and torque values with real-time Lissajous curve display. J Dent & Oral Disord 3(5): 1-5, 2017. |
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AIを活用した全自動電動歯ブラシの開発 |
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外園真規, 井田貴子, 枝並直樹, 永田量子, 竹中彰治, 栄田 源, 横山裕也, 石井裕之, 野杁由一郎. 試作全自動歯ブラシによるデンタルバイオフィルム除去効果. J Health Care Dent. 2022; 23: 47-56 |
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耐性菌の出現を考慮した新規歯周炎制御法の開発 |
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Saito R，Domon H, Hiyoshi T, Hirayama S, Maekawa T, Takenaka S, Noiri Y, Ikeda A, Hirose T, Sunazuka T, Yutaka Terao: A novel 12-membered ring non-antibiotic macrolide EM982 attenuates cytokine production by inhibiting IKKβ and IκBα phosphorylation. Journal of Biological Chemistry 300 (6), 107384, 2024 |
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注：ボールド（太字）は現役教室員 |
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